Glomerular filtration rate what is the rationale and justification of normalizing GFR for body surface area?

Is Body Surface Area the Appropriate Index for Glomerular Filtration Rate?

Indexing glomerular filtration rate (GFR) for body surface area (BSA) is routine practice, but criticism has been raised on indexing GFR for BSA in children, obese and anorectic patients. Over the years other ways of indexing GFR have been proposed, including height, lean body mass, body weight, ideal weight, plasma volume, total body water and especially extracellular volume (ECV). Based on a ...

Indexing glomerular filtration rate for body surface area in obese patients is misleading: concept and example.

1999; 34: 151–159 12. Brenner BM, Garcia DL, Anderson S. Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens 1988; 1: 335–347 13. de Zeeuw D, Remuzzi G, Parving HH et al. Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL. Kidney Int 2004; 65: 2309–2320 14. de Zeeuw D, Remuzzi G, Parving HH et al. Albuminuria, a thera...

FIT to measure glomerular filtration rate ( GFR )

Errors induced by indexing glomerular filtration rate for body surface area: reductio ad absurdum.

In this article, we will discuss an important but underrecognized topic in nephrology. Indeed, indexing glomerular filtration rate (GFR) for body surface area (BSA) is often done by habit, because everyone does it and without raising any questions. Only a scant literature on this topic has been published in recent decades. Regarding guidelines on estimating and measuring GFR, only the Australia...

SERUM CYSTATIN C AS A NEW MARKER OF GLOMERULAR FILTRATION RATE (GFR)

Cystatin C is a 13 KD basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. The cystatin C gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin C by most cells. This protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. Because of the...